Baby's skin is delicate and soft because of its rich HA.

Hyaluronic acid (HA) is a polysaccharide that occurs naturally in human skin. It is formed by the repeated linking of disaccharide units consisting of N-acetylglucosamine and glucuronic acid. HA and sulfated mucopolysaccharide, collagen, elastin and other components together form an extracellular gel-like matrix containing a large amount of water, making the skin flexible and elastic. Due to its excellent moisturizing properties and unique skin feel, HA has been widely used in various categories of skin care products. In 2015, the global use of HA has exceeded 300 tons. With the continuous development of industrialization of HA, new raw materials based on HA have also appeared in the formulator's field of vision.

Ultra-small molecule HA (oligomeric HA) for easy creation of hydro-light muscles

Young and healthy skin is closely related to water content, and the content of HA as an important water-retaining ingredient in the skin directly determines the "visual age" of the skin. The baby's skin is delicate and soft because it is rich in HA. With age, the organism's ability to synthesize HA decreases, HA content decreases so that the skin's water-holding capacity declines, collagen fibers and elastic fibers do not get enough water, and the regular network structure of collagen that expresses skin's luster and elasticity gradually deforms and solidifies. And adhesions, the final performance of rough skin, loss of elasticity, wrinkles and other aging symptoms. The water-light therapy currently popular in the medical and aesthetic field is based on the principle that HA is injected into the dermis of the skin to supplement the missing HA in the skin and stimulate the skin to produce new collagen, effectively delaying the lack of water in the skin due to the dermis. Collagen-induced aging symptoms. Because the water-and-light-muscle effect created by Shuiguangzhen is very significant, and it is highly favored by many consumers, the concept of “water-light” also extends to the field of daily skin care. Recently, cosmetics with the word “shuiguang” appeared. With explosive growth, nearly 1,000 products have been filed in the last three months. The molecular weight of commonly used HA raw materials is over 1 million Da. Such macromolecules cannot actually penetrate the skin barrier, and can complement the loss of HA inside the skin. Therefore, the development of the overcoat hydroponics products requires the use of transdermal HA.

Cellular experiments with oligo-HA showed that it has a variety of biological activities:

(1) Scavenging free radicals. Ultraviolet irradiation induces the production of reactive oxygen species, and the addition of Nano HA before or after irradiation results in a decrease in free radical content.

(2) Promote cell proliferation. Nano-HA can promote the proliferation and differentiation of fibroblasts, reduce or avoid scars, accelerate skin wound healing, and promote wound skin regeneration;

(3) repair damaged cells. Ultraviolet irradiation can cause cell damage, and the cell proliferation rate is greatly reduced. The proliferation rate of cells containing the Nano-HA test group can be increased by 52% compared with the control group, indicating that Nano-HA has a significant effect of repairing and promoting cell proliferation.