hyaluronic acid，HA, also known as hyaluronic acid and hyaluronic acid, is a mucopolysaccharide that is widely present in the body. Hyaluronic acid is present in almost all body tissues and fluids. The important physiological function of hyaluronic acid is to allow moisture to enter the intercellular spaces, and combine with proteins to form protein gels, stick cells together, maintain cell water, protect cells from pathogenic bacteria, and exert normal cellular metabolism. Significant skin moisture, repair and nutrition; adhesion to the surface of articular cartilage and synovial tissue, but also protect cartilage and synovial membrane from damage.

The synthesis of hyaluronic acid in the body is rapid, and it is rapidly excreted or decomposed, and its synthesis is affected by hormones, age, environment and other factors. The level of hyaluronic acid in the skin of adolescent girls (10-20 years old) is the highest, and it decreases with age in adulthood, leading to aging of the body. Oral hyaluronic acid (usually in the form of its sodium salt) can systematically increase the endogenous hyaluronic acid content and provide systemic lubrication and water retention, such as skin, joints, blood vessels, and the heart, in cosmetics, medicine, and foods. All fields have a wide range of applications.

Health function

Improve skin moisture and delay aging

Hyaluronic acid is the skin's most important moisturizing substance, and 2% pure hyaluronic acid aqueous solution can firmly maintain 98% moisture. The maturation and aging process of human skin also changes with the content of hyaluronic acid and metabolism. Dryness, rough skin, wrinkles, loss of elasticity, and moisturizing effects are related to the reduction of hyaluronic acid content in the body. Oral sodium hyaluronate can improve the skin's nutrient metabolism, make the skin soft, smooth, increase elasticity, prevent aging, is called the ideal natural moisturizing factor.

Increase bone density and improve joint function

Supplementation of exogenous sodium hyaluronate can prevent cartilage from degenerative changes, repair and repair the joints with lesions, prevent further destruction and loss of bone matrix, improve the physiological function of synovial fluid, make it play a role in lubrication, reduce Joint friction, ease joint pain, increase joint mobility, promote synovial fluid reflux, limit the spread of inflammatory mediators, relieve and block the vicious circle of joint lesions, protect cartilage and synovial membrane from damage, and ultimately improve knee joint function .

Enhance immunity and suppress tumors

Dendritic cells (DCs) are the most powerful antigen presenting cells found so far and play an integral role in the immune response. One of the main reasons why tumors evade the body's immune system surveillance is that due to the functional defects of DCs, tumor antigens cannot be effectively presented to T lymphocytes and thus can not induce specific cytotoxic T cells to produce effective immune responses. Therefore, tumor immunotherapy for the purpose of promoting DC maturation and enhancing its function has become a hot topic in current research. Studies have shown that in the range of 10-100μg/mL, hyaluronic acid up-regulates IL-12p70 secretion by DCs in a dose-dependent manner, so that tumor growth is significantly inhibited, lymphocyte proliferation reaction, killing activity and cytokines TNF-α and IFN- The expression of γ was significantly increased, demonstrating that hyaluronic acid can promote the maturation of mouse bone marrow DCs and inhibit tumor growth by enhancing anti-tumor immunity.

Hyaluronic acid is the main component of the human connective tissue, and it is present in various parts of the body combined with proteins. Therefore, hyaluronic acid itself has extremely high safety, and its external use grade and food grade acute oral toxicity LD50 of sodium salt> 5000mg/kg, is a practical non-toxic substance, not only can be used as a cosmetic matrix, but also as a medical product, food allowed to go public.

Domestically listed sodium hyaluronate health food

21 health foods with sodium hyaluronate have been listed in the country. Eleven of them were used to increase bone mineral density. Most of them were combined with sodium hyaluronate and collagen, chondroitin sulfate, glucosamine sulphate, vitamin D3, casein phosphopeptide, extract of Rhizoma Drynaria, and calcium compounds; In order to improve skin moisture, sodium hyaluronate is used in combination with collagen, marine fish skin collagen oligopeptide powder, vitamin C, vitamin E, acerola cherry extract, and grape seed extract. A few products have also been approved for use in enhancing immunity, anti-oxidation, and chloasma and other health functions.

Sodium hyaluronate has been approved as a new food ingredient

On May 26, 2008, the former Ministry of Health issued an announcement No. 12 to approve sodium hyaluronate as a new food ingredient.